antiobiotics research and development

R&D

Biotechnological and Chemical company

AdL is a Biotechnological and Chemical company with more than 50 years of experience in the fermentation, purification and synthesis of active pharmaceutical ingredients and intermediates. Its commercial success is strengthened with a versatile R & D department, which is responsible for the improvement of its current processes and the broadening of its product portfolio.

  • R & D provides the company with the newest technologies in this field.
  • Biotechnological and Chemical methodologies are applied for a wide range of production processes in industry.
  • Market Recognized R&D and technical capacity.
  • Recently the company has expanded its interest in the development of non-Pharma products leveraging its R & D capacity.

R&D Department

R&D Department holds a highly skilled team with a solid background in research having access to the modern equipment and adequate facilities to perform the task at its best.

  • 25 experienced people.
  • Nine scientists, Six Ph.D. in Biotechnology and Organic Chemistry.
  • Three graduated in Biotechnology.
  • Eight specialised analysts in fermentative and synthetic tasks.
  • Eight expert technicians in Pilot activities and support in Tech Transfer to manufacturing operation.
  • Recently the company has expanded its interest in the development of non-Pharma products leveraging its R & D capacity.
Research and development department

Main activities

  • Microbial Biotechnology & Microbiology
  • Fermentation Development & Scale-up
  • Purification Development & Scale-up
  • Semi-synthesis and Enzymatic synthesis Design
  • Process Development
  • Assay Development

CMRO activities: Research under contract

We are not just another CRO: due to our extensive volume range, we provide a comprehensive service starting from small lab scale to 1000 L reactors in our plant, all within the same company, which ensures both reliability during scale up and total confidentiality.

  • Development of different fermentation technologies, recovery and purification of biological for third parties.
  • Technology assessment, improvement and transfer of external technologies and products to manufacturing.
  • Development of fermentation, recovery and purification processes for new products and improvement of molecules already in production (fine chemicals, biofuels, antibiotics, enzymes, vitamins, immunosuppresors, antifungals, food additives, renewable chemicals, etc.).

Under previous secret agreement, the Ph.D. responsible of your project will send you confidential reports based on the results obtained, outlining the next steps to be taken focusing on your targets. Our R & D team could also assist you in validation batches, GMP documentation and patent redaction.

Capabilities

At the Upstream Activities (USP), we have both the necessary equipment and a wide experience to perform Biotechnological Research and Development of the main fermentative processes, Four Fs: Food, Feed, Fuel and Functional molecules (new antibiotics, enzymes, vitamins, immunosuppresors, antifungals, amino acids, proteins, biomass, chemical derivatives, fatty acids, etc. and development of fermentation, recovery and purification processes as well.

  • Biological Laboratories: (fermenters 2-5 L, incubation chambers, master cell bank, two strains screening robots,).
  • Fermentation Pilot Plant.
    • 28 Fermenters, 850 L.
    • 2 automated Braun fermenters, 30 L
    • Several smaller tanks
    • Distributed Control System (DCS)

On the Downstream aspects, we also have both the necessary equipment and a wide experience to perform reactions such as asymmetric synthesis, enzymatic resolution, acylation, diazotization, halogenation, reduction, oxidation, hydrogenolysis, esterification, substitution, cycloaddition, Friedel-Crafts, Mannich, amide synthesis, chloride acid synthesis, etc.

We can handle most kinds of reagents (gaseous, hygroscopic, irritant, corrosive, etc.), work with diverse reaction conditions (under pressure, inert atmosphere, etc), Temperature range [-6;200ºC], and isolation conditions (under inert atmosphere, distillation under vacuum, etc.).

  • Chemical Laboratories to carry out the early stages of research.
  • Chemical Pilot Plant.
    • 20 stainless steel reactors, some glazed (glass lined), ranging from 30 to 6,000 liters capacity.
    • Rotary vacuum dryer, vacuum oven, press filter, chromatographic columns, spray-driyer, granulator, spirals membranes plant for UF/MF/RO and other equipment.